Classical and advanced chemical sciences
A complex of formula [MoO2(L)](acac)2 is obtained on treating molybdenyl acetylacetonate with di-2-thienylethanedione with 2,3-diaminotoluene This complex was reacted with four 1,3-diketones to yield four new complexes, [MoO2(ML)](acac)2, The complexes were characterized by elemental analysis, spectral studies and molar conductance. In these compounds, molybdenum exhibited a coordination number of six. Distorted octahedral environment surrounds molybdenum in these complexes. The ligand geometry was completed by two oxo O-atoms and four N-atoms. The synthesized complexes show moderate activity versus S. aureus and S. typhi.
Keywords: Dioxomolybdenum(VI), di-2-thienylethanedione, 1,3-diketones, macrocyclic complexes, Schiff base
Bioactive 1H-indazoles were synthesized from 2-substituted aromatic aldehydes and hydrazine hydrate using DMSO and lemon peel powder as a green and efficient natural catalyst. In comparison to other reported conventional methods, this method affords good yield under ultrasonic irradiation.
Keywords: 2-substituted aldehydes, 1H-indazoles, hydrazine hydrate, natural catalyst, lemon peel powder (LPP)
An HPLC method for Tamsulosin was developed by using a quality by design (QbD) novel concept. QbD has gained importance in recent times due to regulatory requirements in industrial application. Chromatographic separation of Tamsulosin was carried out by using C8 column, and mobile phase used was methanol and distilled water (40:60 v/v) for proper separation process. Separation by using water as a solvent is beneficial as it is cost effective process and industrially applicable. In the development of the HPLC method, factors like injection volume, conc. of methanol, the column vent temperature is critical in maintaining. Hence the Box-Behnken optimization model was applied for the main, interaction and quadratic effects of these three factors on the selected response. The effect of these parameters was studied on the tailing factor (resolution). Results were analysed during a surface diagram. Verification of the software-generated result was done by taking six replicates of the run. Finally, the method was validated according to ICH guidelines.
Keywords: Tamsulosin; QbD approach; RP-HPLC method; Box-Behnken model; ICH guidelines
Materials and environmental chemistry
The objective of this work was to examine the effect of inorganic additives on thermal behavior of homo- and hetero-polymeric hydrogel. Nano SiO2 and TiO2 doped acrylic acid (AA) based homo-polymeric and acrylic acid/vinyl pyrrolidone (AA/VP) based hetero-polymeric hydrogels were synthesized by using in-situ free radical polymerization technique. Additives were used in the ratio of 0.005, 0.5 and 1 (wt %) on AA based homo-polymeric hydrogels. Hetero-polymeric hydrogels were prepared in ratios of 1:3, 2:2 and 3:1 (AA/VP). Additives were used in only AA/VP (3:1) and they were added 0.5 and 1 (wt %). Thermal behaviour of hydrogels, were investigated by TGA-DTA analysis. The effect of doping on pore structure of hydrogels was demonstrated by SEM analysis. SEM/EDX measurements confirmed the presence of additives in the hydrogels. The dispersions of SiO2 and TiO2 on hydrogel were indicated by elemental mapping and their amounts were compared with EDX analysis.
Keywords: Nano-SiO2; TiO2; poly(acrylic acid) (PAA); thermal behavior; hydrogels
Chemical and biological aspects of life
Tumor vasculature is irregularly sized and arranged in a disorganized manner, where they share characteristics of arterioles, capillaries, and venules simultaneously. Studies on microvessels of tissues (from mastopathy to human breast cancer) embedded in Epoxy resins using a light optical microscopy method were performed and human breast cancer microvessel images getting on semithin epoxy slices gave a new opportunity in the studying of this disease.
Keywords: Microvessels; human breast cancer; light optical microscopy; epoxy resins
Paracoccus beibuensis SL2 is a halo-alkalotolerant bacteria isolated from Lonar Crater, Buldhana, Maharashtra, India and was identified by conventional and advanced techniques. The 16s rRNA sequence was deposited to NCBI GenBank with accession number KY129665. In recent studies the bright orange pigment produced by Paracoccus beibuensis SL2 was extracted and purified. The analysis of purified pigment was done by spectrophotometric method, chemical method, TLC, FT-IR and HPLC to know the chemical nature of pigment. The overall studies showed that bright orange pigment produced by Paracoccus beibuensis SL2 is a carotenoid group pigment which is mainly a xanthophyll pigment showing similar characters with that of Astaxanthin. It has a great commercial value as a natural colorant and therapeutic molecule.
Keywords: Paracoccus beibuensis; chemical analysis; pigment