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European chemical bulletinVol. 8., No.11. (2019.)

Tartalom

Classical and advanced chemical sciences

  • Amol Sapkal ,
    Suryakant Sapkal ,
    Balaji Madje :

    Ionic liquid catalyzed one-pot synthesis of hexahydroquinoline derivatives using substituted aryl aldehydes, dimedone, malononitrile and ammonium acetate has been described under microwave irradiation. The protocol has been utilized mild reaction conditions, excellent yield, shorter reaction time and simple workup procedure. The synthesized derivatives were obtained in 80-95% yields and were characterized by IR, 1H NMR, and mass spectra.

    Keywords: Multicomponent reaction; ionic liquid; microwave-irradiation; hexahydroquinolines

  • Sushama Kauthale ,
    Sunil Tekale ,
    Ambadas Rode ,
    Rajesh Patil ,
    Jaiprakash Sangshetti ,
    László Kótai ,
    Rajendra Pawar :

    A series of Schiff’s bases of p-tolylsulphonyl hydrazide were synthesized by using Eaton's reagent under solvent-free condition, characterized by spectroscopic data and for evaluated α-amylase inhibitory activity in vitro. Four among the studied compounds exhibited varying degrees of α-amylase inhibitory activity with IC50 values in the range of 115.48 to 169.42 μg mL-1. The observed results were supported by the molecular docking study performed to understand the binding interaction of the title compounds with the active site of α-amylase enzyme. Results suggest that Schiff's bases of p-tolylsulphonyl hydrazide derivatives can act as potential antidiabetic drugs.

    Keywords: α-Amylase, Eaton's reagent, Schiff's bases, Solvent-free, Molecular docking

  • D. P. Loka Maheshwari ,
    B. Satyanarayana :

    A [bmim][OH] mediated, green and efficient synthesis of phthalazines derivatives have been developed by condensing phthalic acid (1), ethyl cyanohydrazide (2), heteroaromatic aldehydes (3a-3f) and active methylene compounds (4) at 60-65 oC for 60-90 min. The importance of this method includes shorter reaction time and high yield.

    Keywords: Phthalic acid, ethyl cyanohydrazide, active methylene compounds, heteroaromatic aldehydes, [bmim][OH].

  • Dmitry Erzunov ,
    Tatiana Tikhomirova ,
    Dmitry Filippov ,
    Vladimir Maizlish ,
    Igor Abramov ,
    Arthur Vashurin :

    By template condensation of 4-(4-chlorophenoxy)- and 4-(2,4,5-trichlorophenoxy)phthalonitriles with cobalt(II), copper(II) and zinc(II) acetates, the corresponding metal(II) phthalocyaninates were synthesized, and some of their sulfonic acid derivatives were also isolated after sulphonation reactions. The spectroscopic characteristics and some physicochemical properties of the synthesized compounds were also given.

    Keywords: 4-Nitrophthalonitrile; phthalocyanine; synthesis; sulfonation; electronic absorption spectra

Materials and environmental chemistry

  • Ifenna Ilechukwu ,
    Gloria Ihuoma Ndukwe ,
    Nkoli Maryann Mgbemena ,
    Akudo Ugochi Akandu :

    This study investigated the occurrence and abundance of microplastics in surface sediments from four beaches in Lagos State, Nigeria. The beaches are Alpha, Oniru, Eleko and Lekki. Microplastics were taken from the sediments by floatation method. The number of microplastics in 50 g of dry sediment were counted with a photo microscope and results were as follows: Eleko (170 ± 21 items), Lekki (141 ± 36 items), Alpha (133 ± 16 items), and Oniru (121 ± 38 items). Fragments dominated among the microplastics found in the beaches while three polymers; polypropylene (PP), polyethylene (PE) and polystyrene (PS) were identified using Fourier transform infrared spectroscopy (FTIR). This study serves as baseline for further investigations on the occurrence of microplastics in the Nigerian coastal environment.

    Keywords: Microplastics, plastic debris, coastal environment, sediments, Nigeria, beach

Chemical and biological aspects of life

  • Tatia Gonashvili ,
    Ketevan Kotetishvili ,
    Shalva Robitashvili :

    Radiotherapy is one of the most effective treatments for breast cancer. Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) are two recently developed radiotherapy techniques. IMRT is believed to be more effective than 3D-CRT in target coverage, dose homogeneity and reducing toxicity to healthy organs. However, these advantages have not been demonstrated in the treatment of breast cancer. This meta-analysis was performed to compare IMRT and 3D-CRT in the treatment of breast cancer in terms of dose-volume histograms and outcomes, including survival and toxicity.

    Keywords: Oncology; radiotherapy; breast cancer; intensity-modulated radiotherapy (IMRT), three-dimensional conformal radiotherapy (3D-CRT); QA; dosimetry